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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,480 stocks declining versus 1,630 advancing, pointing to a broadly bearish bias.

Dow Jones
52,231.89
Change
-157.86-0.30%
S&P 500
7,520.93
Change
-29.01-0.38%
Nasdaq Composite
25,065.874
Change
-187.265-0.74%
24H Gainers
1,630
24H Losers
3,480

52 Week Gainers

#Stock52 Week Range
4501XORTX Therapeutics Inc.XRTX$0.86+1.76%9.89K$1.57M$0.83 - $3.600.00%
4502OFS Credit Company, Inc.OCCI$1.43-5.96%282.02K$41.97M$1.40 - $5.150.00%
4503Cuprina Holdings (Cayman) LimitedCUPR$1.79-4.32%43.11K$9.36M$1.45 - $14.800.00%
4504Ohmyhome LimitedOMH$16.92-24.57%24.16M$15.67M$2.05 - $109.500.00%
4505Largo Inc.LGO$0.34-4.37%262.98K$38.57M$0.31 - $1.930.00%
4506SelectQuote, Inc.SLQT$0.46+9.68%485.47K$82.36M$0.30 - $1.760.00%
4507enVVeno Medical CorporationNVNO$6.64-2.41%10.76K$4.61M$6.06 - $24.500.00%
4508Estrella Immunopharma, Inc.ESLA$0.76+46.94%3.68M$33.19M$0.24 - $3.000.00%
4509Vyome Holdings, Inc.HIND$1.57-4.80%4.16K$10.99M$1.53 - $5.880.00%
4510Pulmatrix, Inc.PULM$1.39+2.58%8.73K$5.08M$1.06 - $4.980.00%
4511Urban One, Inc.UONE$3.45-14.16%27.33K$2.12M$3.32 - $16.940.00%
4512Gix Internet Ltd.GIXI$3.44-2.55%24.27K$8.85M$3.31 - $15.500.00%
4513Intelligent Bio Solutions Inc.INBS$2.25-3.06%56.55K$7.45M$1.35 - $24.900.00%
4514Enovix CorporationENVX$2.65-4.68%4.09M$580.66M$2.19 - $9.890.00%
4515Gaxos.ai Inc.GXAI$0.42-0.36%393.04K$4.60M$0.34 - $2.630.00%
4516Nouveau Monde Graphite Inc.NMG$0.81-5.15%442.18K$265.30M$0.75 - $3.590.00%
4517Swarmer, Inc.SWMR$8.81-1.78%400.44K$101.49M$6.51 - $83.300.00%
4518Adicet Bio, Inc.ACET$2.98+0.33%377.45K$27.94M$2.86 - $11.200.00%
4519Lexaria Bioscience Corp.LEXX$4.71+3.97%10.31K$9.92M$2.43 - $21.600.00%
4520Lument Finance Trust, Inc.LFT$4.37+0.92%14.30K$22.99M$3.85 - $16.450.65%
4521Pluri Inc.PLUR$1.10-11.02%13.16K$13.87M$0.85 - $4.870.00%
4522Exicure, Inc.XCUR$1.09+21.87%674.33K$7.14M$0.79 - $9.480.00%
4523Uni-Fuels Holdings LimitedUFG$3.04-1.46%7.07K$9.93M$2.06 - $15.600.00%
4524Fundrise Innovation Fund, LLCVCX$21.40+11.37%776.22K$717.73M$18.60 - $575.000.00%
4525SL Science Holding LimitedSLBT$0.93-8.82%21.46K$525.71M$0.74 - $14.500.00%
4526Better Home & Finance Holding CompanyBETR$18.50-7.64%502.79K$245.28M$7.51 - $68.550.00%
4527enGene Therapeutics Inc.ENGN$1.67-5.65%734.09K$112.19M$1.40 - $12.250.00%
4528Borealis Foods Inc.BRLS$0.99-4.23%1.17K$21.36M$0.60 - $3.870.00%
4529Arbe Robotics Ltd.ARBE$0.46-3.02%301.35K$58.69M$0.39 - $1.940.00%
4530Frontier Nuclear and Minerals Inc.FNUC$0.71-8.21%177.04K$25.38M$0.61 - $2.820.00%
4531Jasper Therapeutics, Inc.JSPR$14.68-10.38%46.83K$18.70M$9.45 - $72.600.00%
4532QuantumScape CorporationQS$4.46-2.52%14.75M$2.63B$3.80 - $17.580.00%
4533Primech Holdings Ltd.PMEC$0.33-7.61%15.23K$12.60M$0.26 - $1.370.00%
4534Cosmos Holdings Inc.COSM$0.20-26.21%7.25M$19.93M$0.16 - $0.820.00%
4535Skillsoft Corp.SKIL$3.11-7.16%44.04K$28.30M$3.06 - $13.040.00%
4536Creative Global Technology Holdings LimitedCGTL$2.47+2.15%4.04K$4.13M$2.27 - $96.000.00%
4537Liberty Defense Holdings, LtdDETX$1.23+6.96%7.18K$6.99M$1.12 - $4.980.00%
4538Alight, Inc.ALIT$12.21-3.48%407.83K$322.91M$7.93 - $49.400.06%
4539SoundHound AI, Inc.SOUN$3.87-4.57%22.49M$1.59B$3.71 - $14.980.00%
4540WF International LimitedWXM$2.20-0.58%23.79K$6.86M$1.27 - $12.800.00%
4541Fangdd Network Group LtdDUO$0.57+6.11%26.06K$21.96M$0.42 - $2.440.00%
4542SPAR Group Inc.SGRP$0.28-45.07%3.31M$0$0.27 - $1.090.00%
4543Ambitions Enterprise Management Co. L.L.CAHMA$1.23+10.31%51.42K$33.29M$0.76 - $39.500.00%
4544ClearSign Technologies CorporationCLIR$2.47-3.28%11.54K$16.84M$2.12 - $9.800.00%
4545Ramaco Resources, Inc.METCB$3.97-3.82%18.79K$45.71M$3.43 - $16.120.00%
4546Big Tree Cloud Holdings LimitedDSY$3.05-2.68%3.43K$15.11M$1.67 - $19.900.00%
4547Ramaco Resources, Inc.METC$6.56-3.89%1.16M$340.09M$5.73 - $28.670.00%
4548Enveric Biosciences, Inc.ENVB$1.51+5.56%37.50K$6.75M$1.17 - $13.250.00%
4549BitFuFu Inc.FUFU$0.85-9.92%47.37K$26.97M$0.64 - $3.470.00%
4550Advanced Biomed Inc.ADVB$2.12-2.57%13.30K$3.51M$1.80 - $24.230.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
XORTX Therapeutics Inc. (XRTX) currently leads with a 52-week gain of 70.92% as of 2026-11-11 04:30 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.