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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,481 stocks declining versus 1,630 advancing, pointing to a broadly bearish bias.

Dow Jones
52,231.89
Change
-157.86-0.30%
S&P 500
7,520.93
Change
-29.01-0.38%
Nasdaq Composite
25,065.874
Change
-187.265-0.74%
24H Gainers
1,630
24H Losers
3,481

52 Week Gainers

#Stock52 Week Range
4151Wave Life Sciences Ltd.WVE$3.40-2.30%1.09M$663.68M$3.04 - $21.730.00%
4152Pliant Therapeutics, Inc.PLRX$0.78-2.14%350.51K$48.48M$0.77 - $1.810.00%
4153CLEANSPARK INC.CLSK$6.57-4.92%14.21M$1.69B$5.53 - $19.170.02%
4154New Era Energy & Digital, Inc.NUAI$2.06-6.82%7.20M$242.79M$1.57 - $9.450.00%
4155CBL International LimitedBANL$2.89-3.35%20.43K$6.07M$2.77 - $16.390.00%
4156Cre8 Enterprise LimitedCRE$2.54+3.01%19.18K$4.17M$1.68 - $8.600.00%
4157Alignment Healthcare, Inc.ALHC$7.68+5.78%3.29M$1.61B$6.01 - $25.120.00%
4158LegalZoom.com, Inc.LZ$4.71-2.68%2.87M$778.73M$4.54 - $10.510.00%
4159MDB Capital Holdings, LLCMDBH$1.63+1.24%1.08K$8.86M$0.89 - $4.160.00%
4160Twenty One Capital, Inc.XXI$5.32-3.23%1.11M$1.90B$4.15 - $12.510.00%
4161XBP Global Holdings, Inc.XBP$2.79-4.58%8.48K$39.51M$2.00 - $8.550.00%
4162Clene Inc.CLNN$4.43+1.14%142.01K$63.79M$3.02 - $10.840.00%
4163Orthofix Medical Inc.OFIX$7.12-10.00%892.81K$289.89M$6.52 - $16.420.00%
4164Teamshares Inc.TMS$5.78+12.09%49.50K$352.58M$3.88 - $13.200.00%
4165Avalo Therapeutics, Inc.AVTX$7.17-1.65%3.73M$386.36M$6.53 - $24.270.00%
4166Forge Nano Holdings Inc.NANO$4.67+9.76%126.01K$545.50M$3.12 - $11.960.00%
4167monday.com Ltd.MNDY$76.32-4.52%1.27M$3.90B$57.50 - $169.760.00%
4168Lite Strategy, Inc.LITS$0.96+1.63%270.11K$29.19M$0.69 - $2.200.00%
4169comScore, Inc.SCOR$3.12-7.42%55.22K$47.38M$3.05 - $9.340.00%
4170TH International LimitedTHCH$1.23-1.29%9.91K$44.85M$1.00 - $2.730.00%
4171PharmaCyte Biotech, Inc.PMCB$0.40-0.61%77.46K$4.34M$0.30 - $1.510.07%
4172Beamr Imaging Ltd.BMR$0.97-7.57%58.83K$15.06M$0.96 - $2.510.00%
4173Aether Holdings, Inc.ATHR$2.66+6.40%7.83K$28.88M$1.87 - $6.860.00%
4174Galaxy Digital Inc.GLXY$14.10-2.79%5.78M$2.60B$11.78 - $36.100.00%
4175Humacyte, Inc.HUMA$0.59+25.90%15.26M$163.07M$0.34 - $1.520.00%
4176Connect Biopharma Holdings LimitedCNTB$0.70-7.76%396.76K$43.89M$0.68 - $3.820.00%
4177Whirlpool Corp.WHR$30.30-4.05%2.36M$1.99B$25.50 - $94.820.06%
4178TripAdvisor, Inc.TRIP$7.09-0.49%9.21M$830.59M$6.78 - $16.040.00%
4179Mount Logan Capital Inc.MLCI$3.57+1.71%12.26K$41.29M$2.56 - $8.680.00%
4180Black Hawk Acquisition CorporationBKHA$5.13-1.54%3.84K$21.31M$3.70 - $23.000.00%
4181ReposiTrak, Inc.TRAK$6.86-3.93%70.97K$124.79M$6.61 - $15.440.01%
4182BitMine Immersion Technologies, Inc.BMNR$18.07-2.53%27.88M$10.90B$12.80 - $42.090.00%
4183Hyperion DeFi, Inc.HYPD$2.57-1.94%156.80K$40.00M$2.34 - $6.000.02%
4184Integrated Media Technology LimitedIMTE$0.38+2.86%27.50K$1.32M$0.30 - $1.100.00%
4185Fulcrum Therapeutics, Inc.FULC$3.71+0.13%789.12K$283.76M$2.83 - $15.740.00%
4186Global Engine Group Holding LimitedGLE$2.22-2.43%6.36K$5.44M$1.42 - $10.800.00%
4187Fly-E Group, Inc.FLYE$2.46+14.35%106.87K$4.02M$1.22 - $21.800.00%
4188Protara Therapeutics, Inc.TARA$2.44-2.79%399.33K$144.25M$2.09 - $7.820.00%
4189PetMed Express, Inc.PETS$1.23-1.60%112.14K$26.56M$1.15 - $4.100.00%
4190JELD-WEN Holding, Inc.JELD$1.01-12.17%0$88.08M$0.93 - $3.270.00%
4191Greenland Technologies Holding CorporationGTEC$0.54+9.59%76.70K$9.34M$0.42 - $1.610.27%
4192GBank Financial Holdings Inc.GBFH$15.35-1.09%34.76K$222.81M$11.51 - $38.000.00%
4193Foxx Development Holdings Inc.FOXX$1.57-1.20%4.44K$11.32M$1.49 - $7.900.00%
4194Insulet CorporationPODD$148.05-1.19%869.49K$10.27B$126.40 - $354.880.00%
4195Eve Holding, Inc.EVEX$2.00+2.05%933.64K$695.26M$1.41 - $5.160.00%
4196Altimmune, Inc.ALT$1.94-8.73%3.79M$376.39M$1.90 - $6.440.00%
4197Embecta Corp.EMBC$6.42+0.08%647.64K$363.81M$2.77 - $14.910.07%
4198P3 Health Partners Inc.PIII$3.38-18.82%742.89K$13.56M$1.52 - $16.890.00%
4199Destination XL Group, Inc.DXLG$0.42-0.47%31.45K$23.40M$0.36 - $1.580.00%
4200ONE Nuclear Energy Inc.ONEN$1.55+7.78%51.58K$165.41M$1.22 - $3.650.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Wave Life Sciences Ltd. (WVE) currently leads with a 52-week gain of 53.10% as of 2026-11-11 07:07 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.