52-Week Top Losing U.S. stocks
Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.

Market Overview
U.S. stocks are broadly lower today, with the Dow Jones down 0.33%, the S&P 500 down 0.46%, and the Nasdaq Composite down 0.87%. Market breadth is negative, with 3,589 stocks declining versus 1,521 advancing, pointing to a broadly bearish bias.
52 Week Losers
| # | Stock | 52 Week Range | |||||
|---|---|---|---|---|---|---|---|
| 5101 | Butterfly Network, Inc.BFLY | $6.51 | -2.40% | 3.66M | $1.60B | $1.90 - $10.21 | 0.00% |
| 5102 | Tilly's Inc.TLYS | $4.12 | -2.61% | 129.84K | $95.92M | $1.14 - $6.25 | 0.00% |
| 5103 | Bandwidth Inc.BAND | $43.58 | +4.12% | 467.92K | $1.33B | $12.50 - $79.08 | 0.00% |
| 5104 | American Well CorporationAMWL | $12.05 | -3.53% | 143.45K | $187.59M | $3.71 - $15.16 | 0.00% |
| 5105 | Prelude Therapeutics IncorporatedPRLD | $3.77 | +0.13% | 336.49K | $300.62M | $1.17 - $6.83 | 0.00% |
| 5106 | Absci CorporationABSI | $9.96 | -7.73% | 3.81M | $1.71B | $2.24 - $12.54 | 0.00% |
| 5107 | Rallybio CorporationRLYB | $15.77 | -0.99% | 16.96K | $84.88M | $3.67 - $17.57 | 0.00% |
| 5108 | SAIHEAT LimitedSAIH | $22.31 | +6.34% | 4.44K | $26.67M | $5.90 - $33.00 | 0.00% |
| 5109 | Able View Global Inc.ABLV | $2.40 | +3.36% | 120.88K | $58.97M | $0.54 - $2.96 | 0.00% |
| 5110 | Tango Therapeutics, Inc.TNGX | $24.29 | +6.82% | 3.75M | $4.10B | $7.49 - $34.39 | 0.00% |
| 5111 | Century Therapeutics, Inc.IPSC | $1.69 | -7.18% | 646.14K | $305.11M | $0.43 - $3.04 | 0.00% |
| 5112 | LB Pharmaceuticals Inc.LBRX | $44.91 | -0.40% | 338.88K | $1.36B | $14.32 - $50.16 | 0.00% |
| 5113 | Revolution Medicines, Inc.RVMD | $193.16 | -3.50% | 1.44M | $41.78B | $61.50 - $224.31 | 0.00% |
| 5114 | AbCellera Biologics Inc.ABCL | $12.45 | -0.24% | 3.54M | $3.82B | $2.75 - $15.02 | 0.00% |
| 5115 | Entravision CommunicationEVC | $9.10 | -2.04% | 1.33M | $754.88M | $2.56 - $13.74 | 0.02% |
| 5116 | ImmunityBio, Inc.IBRX | $6.75 | -5.13% | 18.73M | $7.15B | $1.95 - $12.43 | 0.00% |
| 5117 | RF Acquisition Corp IIRFAI | $33.80 | +7.78% | 4.93K | $118.74M | $8.94 - $73.00 | 0.00% |
| 5118 | Sandisk CorporationSNDK | $859.76 | -2.98% | 12.21M | $118.82B | $183.00 - $2,354.39 | 0.00% |
| 5119 | GIBO Holdings LimitedGIBO | $149.60 | -21.89% | 11.43K | $456.50M | $22.60 - $194.91 | 0.00% |
| 5120 | Relay Therapeutics, Inc.RLAY | $19.92 | -2.11% | 1.90M | $4.40B | $5.95 - $21.27 | 0.00% |
| 5121 | Vera Bradley, Inc.VRA | $8.00 | -0.75% | 543.00K | $229.60M | $1.39 - $8.35 | 0.00% |
| 5122 | Iovance Biotherapeutics, Inc.IOVA | $8.08 | -1.04% | 8.70M | $3.66B | $2.08 - $15.37 | 0.00% |
| 5123 | OmniAb, Inc.OABI | $5.10 | -3.77% | 1.57M | $743.30M | $1.35 - $5.45 | 0.00% |
| 5124 | Ampco-Pittsburgh Corp.AP | $6.72 | +13.33% | 156.14K | $138.93M | $1.75 - $12.81 | 0.00% |
| 5125 | Nuvectis Pharma, Inc.NVCT | $20.97 | +0.29% | 175.12K | $721.27M | $5.77 - $29.27 | 0.00% |
| 5126 | Alpha Tau Medical Ltd.DRTS | $13.71 | -2.91% | 391.59K | $1.24B | $3.43 - $15.79 | 0.00% |
| 5127 | MaxLinear, Inc.MXL | $53.77 | -3.84% | 1.94M | $4.89B | $12.77 - $128.30 | 0.00% |
| 5128 | Pulse Biosciences, Inc.PLSE | $55.08 | -5.28% | 455.60K | $4.05B | $12.56 - $58.94 | 0.00% |
| 5129 | Quhuo LimitedQH | $3.07 | +8.43% | 12.46K | $7.43M | $0.07 - $12.81 | 0.00% |
| 5130 | AN2 Therapeutics, Inc.ANTX | $4.33 | +8.50% | 252.78K | $163.40M | $1.00 - $7.19 | 0.00% |
| 5131 | 10x Genomics, Inc.TXG | $62.87 | -3.34% | 2.02M | $7.56B | $15.12 - $102.81 | 0.00% |
| 5132 | AXT Inc.AXTI | $39.30 | -8.40% | 8.52M | $2.58B | $8.44 - $143.16 | 0.00% |
| 5133 | MindForge Inc.MF | $16.16 | -0.52% | 181.34K | $67.76M | $3.80 - $25.90 | 0.00% |
| 5134 | Q32 Bio Inc.QTTB | $9.34 | +1.39% | 295.29K | $279.43M | $1.91 - $23.57 | 0.00% |
| 5135 | Oruka Therapeutics, Inc.ORKA | $109.78 | +4.99% | 2.45M | $7.27B | $25.23 - $115.52 | 0.00% |
| 5136 | PACS Group, Inc.PACS | $49.11 | +0.68% | 520.91K | $7.79B | $10.31 - $51.68 | 0.01% |
| 5137 | Veradermics, IncorporatedMANE | $148.57 | +2.52% | 561.67K | $5.80B | $32.00 - $152.35 | 0.00% |
| 5138 | Fossil Group, Inc.FOSL | $7.90 | +20.47% | 978.51K | $467.31M | $1.70 - $8.25 | 0.00% |
| 5139 | Eton Pharmaceutcials, Inc.ETON | $67.60 | +4.91% | 1.08M | $1.95B | $14.27 - $68.32 | 0.00% |
| 5140 | Anterix Inc.ATEX | $75.91 | -6.36% | 259.32K | $1.49B | $17.82 - $113.00 | 0.00% |
| 5141 | Energys Group LimitedENGS | $4.95 | +5.10% | 10.89M | $268.23M | $0.57 - $5.00 | 0.00% |
| 5142 | Twist Bioscience CorporationTWST | $132.07 | -2.48% | 1.48M | $8.28B | $23.30 - $219.71 | 0.00% |
| 5143 | Avita Medical, Inc.RCEL | $17.64 | +2.89% | 811.31K | $554.25M | $3.22 - $18.43 | 0.00% |
| 5144 | Spyre Therapeutics, Inc.SYRE | $104.46 | -4.18% | 809.03K | $9.92B | $21.63 - $110.64 | 0.00% |
| 5145 | New Century Logistics (BVI) LimitedNCEW | $16.96 | -1.45% | 73 | $54.26M | $2.80 - $20.83 | 0.00% |
| 5146 | Vince Holding Corp.VNCE | $12.87 | -1.83% | 205.54K | $166.53M | $1.95 - $13.90 | 0.00% |
| 5147 | CareDx, Inc.CDNA | $80.86 | -4.38% | 879.31K | $4.25B | $15.15 - $90.87 | 0.00% |
| 5148 | BUUU Group LimitedBUUU | $4.29 | -8.72% | 286.60K | $1.05B | $0.57 - $8.10 | 0.00% |
| 5149 | Space Exploration Technologies Corp.SPCX | $143.15 | +0.72% | 77.44M | $1.82T | $21.32 - $225.64 | 0.00% |
| 5150 | SELLAS Life Sciences Group, Inc.SLS | $8.36 | -2.45% | 3.46M | $1.69B | $1.39 - $15.88 | 0.00% |
Trade U.S. stocks Your Way on MEXC
| RealStocks | Tokenized Stocks | Stock Futures | |
|---|---|---|---|
| What it is | RealStocks — real shares of U.S.-listed companies | Blockchain-based tokens linked to U.S. stocks/ETFs | USDT-margined futures on U.S. stock price movements |
| Ownership | Yes — actual shares | No — synthetic exposure only | No — derivative exposure only |
| Shareholder rights | Yes (e.g. dividends) | No | No |
| Trading hours | U.S. market sessions (pre-market, regular, after-hours, overnight) | 24/7 | Up to 24/7 (supported pairs) |
| Position types | Buy and hold | Buy and hold | Long, short, leveraged |
| Best for | Long-term investors seeking ownership and dividend income | Traders wanting round-the-clock access to stock exposure without holding shares | Active/short-term traders looking to speculate or hedge with leverage |
Why Trade U.S. stocks on MEXC?
RealStocks, Real Ownership
Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.
7,000+ U.S. stocks & ETFs
Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.
Seamless USDT-to-Stock Access
Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.
Lower-Cost Stock Trading
Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.
Frequently Asked Questions (FAQ)
What are 52-week top losing U.S. stocks?
How is the 52-week decline measured?
Which stock has fallen the most over 52 weeks?
Why track 52-week stock losers?
Is a 52-week loser automatically a value stock?
How is this different from Top Losers?
Discover Top US Stocks
Disclaimer
US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.









.b39e813829fa.png)

.b39e815d234d.png)
.b39e81c62f33.png)
.b39e81f7d220.png)
