52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,483 stocks declining versus 1,627 advancing, pointing to a broadly bearish bias.

Dow Jones

52,231.89

Change

-157.86-0.30%

S&P 500

7,520.93

Change

-29.01-0.38%

Nasdaq Composite

25,065.874

Change

-187.265-0.74%

24H Gainers

1,627

24H Losers

3,483

52 Week Gainers

Large Cap Small Cap 52 Week Gainers 52 Week Losers Semiconductor Software Biotech Bank

#	Stock					52 Week Range
51	Century Therapeutics, Inc.IPSC	$1.69	-7.18%	646.14K	$305.11M	$0.43 - $3.04	0.00%
52	Tango Therapeutics, Inc.TNGX	$24.29	+6.82%	3.75M	$4.10B	$7.49 - $34.39	0.00%
53	Able View Global Inc.ABLV	$2.40	+3.36%	120.88K	$58.97M	$0.54 - $2.96	0.00%
54	SAIHEAT LimitedSAIH	$22.31	+6.34%	4.44K	$26.67M	$5.90 - $33.00	0.00%
55	Rallybio CorporationRLYB	$15.77	-0.99%	16.96K	$84.88M	$3.67 - $17.57	0.00%
56	Absci CorporationABSI	$9.96	-7.73%	3.81M	$1.71B	$2.24 - $12.54	0.00%
57	Prelude Therapeutics IncorporatedPRLD	$3.77	+0.13%	336.49K	$300.62M	$1.17 - $6.83	0.00%
58	American Well CorporationAMWL	$12.05	-3.53%	143.45K	$187.59M	$3.71 - $15.16	0.00%
59	Bandwidth Inc.BAND	$43.58	+4.12%	467.92K	$1.33B	$12.50 - $79.08	0.00%
60	Tilly's Inc.TLYS	$4.12	-2.61%	129.84K	$95.92M	$1.14 - $6.25	0.00%
61	Butterfly Network, Inc.BFLY	$6.51	-2.40%	3.66M	$1.60B	$1.90 - $10.21	0.00%
62	Lindblad Expeditions Holdings Inc.LIND	$35.39	-0.88%	390.26K	$2.32B	$11.37 - $38.85	0.00%
63	Septerna, Inc.SEPN	$52.34	+2.90%	476.77K	$2.28B	$17.98 - $52.59	0.00%
64	EuroDry LtdEDRY	$38.81	+0.85%	137.32K	$111.27M	$12.30 - $73.07	0.00%
65	Xencor, Inc.XNCR	$39.43	+2.15%	979.96K	$2.96B	$10.38 - $40.05	0.00%
66	Micron Technology, Inc.MU	$725.01	-1.19%	25.29M	$820.30B	$192.59 - $1,255.00	0.00%
67	Elite Express Holding Inc.ETS	$1.50	-1.94%	20.71K	$54.35M	$0.39 - $2.75	0.00%
68	First Tracks Biotherapeutics, Inc.TRAX	$52.33	+5.25%	1.07M	$2.01B	$14.72 - $54.85	0.00%
69	Iridium Communications Inc.IRDM	$46.15	+2.41%	700.66K	$4.90B	$15.64 - $57.18	0.01%
70	Andersen Group Inc.ANDG	$65.50	-0.05%	776.39K	$1.21B	$18.12 - $68.41	0.00%
71	Hinge Health, Inc.HNGE	$123.25	+0.85%	1.00M	$9.34B	$30.08 - $124.94	0.00%
72	American Outdoor Brands, Inc.AOUT	$18.70	+2.02%	143.94K	$236.08M	$6.26 - $19.50	0.00%
73	Surrozen, Inc.SRZN	$32.67	+2.22%	173.15K	$379.29M	$11.66 - $37.83	0.00%
74	Enliven Therapeutics, Inc.ELVN	$51.29	-0.56%	789.17K	$3.77B	$14.79 - $62.32	0.00%
75	Kelly Services Inc.KELYB	$24.82	-2.50%	3.72K	$81.79M	$8.38 - $125.00	0.01%
76	Cumberland Pharmaceuticals Inc.CPIX	$5.37	-0.65%	183.95K	$80.41M	$1.85 - $9.28	0.00%
77	RINGCENTRAL, INC.RNG	$73.34	+0.74%	734.49K	$5.48B	$24.14 - $98.14	0.00%
78	Glaukos CorporationGKOS	$236.29	-1.07%	599.93K	$13.99B	$83.78 - $255.19	0.00%
79	Replimune Group, Inc.REPL	$23.29	+4.58%	2.75M	$2.21B	$1.50 - $23.40	0.00%
80	DHI Group, Inc.DHX	$4.50	+5.63%	153.22K	$191.14M	$1.44 - $5.19	0.00%
81	TOP Financial Group LimitedTOP	$14.70	-7.34%	289.10K	$1.64B	$3.06 - $17.42	0.00%
82	Vestis CorporationVSTS	$14.36	-0.76%	453.08K	$1.90B	$5.00 - $16.90	0.00%
83	Omeros CorporationOMER	$17.29	-1.54%	522.42K	$1.25B	$6.24 - $21.24	0.00%
84	QTREX Quantum Ltd.QTEX	$1.02	-2.83%	1.98M	$57.36M	$0.28 - $3.85	0.00%
85	Trueblue, Inc.TBI	$12.68	+4.36%	272.23K	$386.60M	$3.18 - $13.59	0.00%
86	Immix Biopharma, Inc.IMMX	$8.36	-2.33%	646.42K	$597.78M	$3.16 - $15.10	0.00%
87	Sezzle Inc.SEZL	$149.50	-0.97%	342.05K	$5.05B	$49.50 - $195.71	0.00%
88	Agencia Comercial Spirits LtdAGCC	$14.72	+3.20%	226.43K	$600.29M	$5.00 - $25.73	0.00%
89	Shattuck Labs, Inc.STTK	$4.86	-2.81%	594.76K	$487.26M	$1.72 - $8.33	0.00%
90	Maase Inc.MAAS	$9.76	-9.46%	49.25K	$4.25B	$3.66 - $24.90	0.00%
91	Syntec Optics Holdings, Inc.OPTX	$5.42	+3.24%	1.41M	$218.28M	$1.18 - $14.92	0.00%
92	Edgewise Therapeutics, Inc.EWTX	$46.54	-4.55%	1.78M	$5.10B	$16.98 - $48.93	0.00%
93	Amylyx Pharmaceuticals, Inc.AMLX	$30.93	+2.33%	1.30M	$3.45B	$10.83 - $41.14	0.00%
94	Maravai LifeSciences Holdings, Inc.MRVI	$7.86	-1.93%	1.18M	$1.17B	$2.80 - $9.42	0.00%
95	FIGS, Inc.FIGS	$22.39	+4.12%	3.12M	$3.53B	$8.36 - $22.53	0.00%
96	Lulu's Fashion Lounge Holdings, Inc.LVLU	$11.43	+9.93%	35.60K	$32.82M	$4.38 - $32.32	0.00%
97	Ultralife CorporationULBI	$15.79	+0.67%	72.80K	$263.08M	$4.90 - $15.79	0.00%
98	Noodles & CompanyNDLS	$14.07	-1.56%	18.86K	$83.98M	$3.57 - $19.00	0.00%
99	Lifetime Brands, Inc.LCUT	$7.96	+6.48%	122.89K	$182.96M	$3.02 - $10.17	0.02%
100	Starz Entertainment Corp.STRZ	$26.04	+0.27%	168.03K	$425.25M	$8.40 - $32.58	0.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?

These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.

How is the 52-week gain calculated?

It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.

Which stock has gained the most over 52 weeks?

Century Therapeutics, Inc. (IPSC) currently leads with a 52-week gain of 207.20% as of 2026-11-11 00:06 UTC.

Why use a 52-week stock performance ranking?

It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.

Does strong 52-week performance guarantee future gains?

No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.

How is this different from the daily Top Gainers list?

The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

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Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.